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CRISPR hybrid RNA-DNA gene editing is a cutting-edge technology that combines the precision of CRISPR-Cas9 with the stability of DNA-RNA hybrids for targeted genome modifications. This method enhances editing efficiency and reduces off-target effects, making it ideal for developing allogeneic cell therapies. It holds significant potential for advancing treatments for genetic disorders, cancers, and immune-related diseases, offering a more reliable and scalable approach to gene editing.