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The acute inflammatory response is well-known for its enhanced vascular permeability, increased blood flow, and neutrophil and macrophage infiltration. Furthermore, fluid and plasma protein exudation, as well as leukocyte buildup at the inflammatory site, frequently cause edema. Researchers have described various experimental models of paw edema. As one of the best defined acute inflammatory models, the carrageenan-induced mouse/rat model is increasingly being utilized to test new anti-inflammatory medications and explore the causes of inflammation.

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