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Circle-Seq-based eccDNA (extrachromosomal circular DNA) identification provides a novel dimension to cancer research. EccDNAs, circular DNA molecules that exist outside chromosomes, are frequently abundant in cancer cells and are implicated in tumor evolution, drug resistance, and genomic plasticity. Circle-Seq is a highly sensitive technique designed to detect and characterize eccDNAs, offering insights into their roles and potential as diagnostic or therapeutic biomarkers. By integrating WES with Circle-Seq, a comprehensive view of the cancer genome can be achieved, capturing both point mutations and structural variations.